Adaptation to climate change implies that concerned strategies and plans need to be checked and modified frequently. This means that up to date data and knowledge must be gathered and related to already existing data and knowledge in order to find out what is still valid and what should be adjusted. It becomes clear in this chapter that a specific form of knowledge management is required. The availability of local and regional as well as world wide data and analysis of these and of developing patterns with respect to the various climate change indicators are of crucial importance for considering new measures and investments. In this respect, new questions may arise and additional research can be required to answer these and to clarify upcoming problem situations, also in terms of complex adaptive decision making and investments. New knowledge is often followed by innovations which could deliver alternative insights and solutions. Adaptive management expects a large investment in knowledge, research, and innovation, all of which are interconnected. For addressing the items on the Delta Plan knowledge agenda, the vast body of technology, practical experiences and knowledge capabilities of universities, research institutions, and business sector enterprises can be utilized. The necessity of institutional and interministerial research and knowledge coordination is yet another challenge. A knowledge management method must be anchored and coordinated in the adaptation process, as the BDP 2100 is meant to be continually scientific and knowledge driven. In light of this, the goal of this chapter is to define the key concerns and components for a knowledge development strategy and knowledge agenda, as well as to emphasize the context and contemporary knowledge management techniques and factors pertinent to adaptive management.