The research explores the impact of transportation use and regional transport infrastructure on enhancing the efficiency of transport and logistics services in Uzbekistan. During the research, the authors conducted a comparative analysis of the coefficients representing the density of the transport network in the regions for 2021 and 2022. For 2022, the authors developed regression equations to represent the influence of regional transport infrastructure indicators on socio-economic outcomes in Uzbekistan. The analysis examined the effects of these factors, revealing that Andijan, Fergana, and Namangan have high transport network density, while the Republic of Karakalpakstan, Navoi, and Bukhara have lower density. The correlation analysis shows that a 1% change in the number of cars, the length of paved roads, and the length of public railways in a region results in more than a 0.5% change in the region’s GRP. Therefore, enhancing transport infrastructure indicators can further stimulate regional economic development.