Isogeometric Analysis (IGA) uses higher-order and higher-continuity spline basis functions known from Computer Aided Design (CAD) to describe the geometry and the solution field of the simulation model (mainly Non-Uniform Rational B-splines). This leads to a more accurate geometry description, a smooth solution field and therefore superior simulation properties compared to traditional Finite Element Analysis (FEA). Using the same geometry description for CAD and IGA also speeds up the modeling process for the simulation. Real components consist of multiple sheet metal parts connected by point-like joints (spot-welds, rivets, screws). These joints significantly influence the component behaviour under crash load. Therefore, their properties must be accurately described within the component simulation. Due to minimum time step requirements a detailed modelling of every single joint is impossible. Thus, substitute models are used in component simulations, which describe the joints behaviour based on constrained conditions between the joining partners. However, these substitute models are developed for traditional FEA. To enable the application of IGA to vehicle simulations, this paper investigates whether existing constrained-based substitute models (e.g. *CONSTRAINED_SPR3 spotweld elements) can be combined with isogeometric shell models without further modifications. Therefore, specimen and component tests are simulated with IGA and FEA. The simulation results are compared to each other as well as experimental test results. It can be shown that IGA achieves a very good agreement with the experimental results, with a prediction quality comparable to the traditional FEA. This allows a straightforward replacement of existing FEA shell components with their IGA counterparts in vehicle simulations.