The increasing use of artificial intelligence (AI) in businesses has brought challenges regarding its adoption and ethical practices in businesses. Therefore, this chapter aims to assess the challenges of AI in the business sector from an ethical perspective. By applying a systematic literature review (SLR) approach, three research areas were identified: first, the impact and integration of AI technology; second, AI governance challenges; and third, corporate social responsibility and human-centered AI. The first cluster highlights AI’s integration into companies and the transformation of business operations. The second cluster shows that the search for efficiency and better decision-making among businesses has increased risks, particularly those related to the misuse of data by AI and the need for greater transparency from businesses. The third cluster centers on mitigating AI’s societal and economic impacts, particularly regarding job displacement and changing consumer attitudes. The chapter’s findings emphasize the ethical challenges businesses face when adopting AI and the necessity of balancing efficiency and profit with social responsibility. Several implications are drawn. As human-AI interaction continues to evolve, regular updates are required to answer the technology development and to gain customer trust and loyalty.