De Quervain’s disease, or tenosynovitis, affects tendons in the first extensor compartment of the wrist, causing pain and inflammation. Diagnosis involves clinical history and physical exams, with ultrasound aiding in precise identification. Treatment includes immobilization, anti-inflammatory drugs, and corticosteroids, with ultrasound-guided injections showing high success rates. Surgical release is an option if conservative measures fail, with minimally invasive techniques like endoscopic release developed to reduce complications. Ultrasound-guided release, performed by experienced surgeons, has shown over 90% success rates due to precise localization and targeted treatment delivery. Candidates for this technique have De Quervain’s disease without response to conservative treatment. Surgery is performed under local anesthesia with ultrasound guidance, freeing the affected tendons to allow for faster recovery. Postoperative care involves wound care, exercises, and pain management. This technique offers a cost-effective, efficient alternative to open surgery for De Quervain’s disease.