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A 55-year-old male presented with a longstanding history of pruritic rash on his back and incidentally discovered V-nicking of his nails. Histologic examination of the rash was consistent with a diagnosis of Darier disease. Darier disease is a rare genetic disorder that occurs due to mutations in the ATP2A2 gene. The disease typically presents in childhood with pruritic hyperkeratotic papules coalescing into plaques in a seborrheic distribution. Nail abnormalities (such as V-nicking, brittle nails, and candy cane nails) are common.

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Darier Disease with V-Nicking of the Nails

  • 章节

  • 发表日期：

    2025年

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  • Madelyn M. Class,
  • David Smith,
  • Ryan P. Johnson,
  • Nadia Abidi,
  • Mary M. Braden,
  • Farhaan Hafeez,
  • Andrew C. Krakowski

摘要

A 55-year-old male presented with a longstanding history of pruritic rash on his back and incidentally discovered V-nicking of his nails. Histologic examination of the rash was consistent with a diagnosis of Darier disease. Darier disease is a rare genetic disorder that occurs due to mutations in the ATP2A2 gene. The disease typically presents in childhood with pruritic hyperkeratotic papules coalescing into plaques in a seborrheic distribution. Nail abnormalities (such as V-nicking, brittle nails, and candy cane nails) are common.