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The treatment of chromoblastomycosis is still not defined, without a well-established standard treatment. It is associated with low cure and high recurrence rates, leading to long treatment. Therapy options depend on the extent of the lesions, location and patient’s comorbidities. We report an unusual case of chromoblastomycosis (Fonsecaea pedrosoi) treated exclusively with topical 5% imiquimod (5times/week for 9 months), followed by complete involution of the clinical lesions, and no recurrence after 4 years of follow-up.

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Periungual Chromoblastomycosis Successfully Treated with 5% Topical Imiquimod

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  • 发表日期：

    2025年

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  • Nilton Gioia Di Chiacchio,
  • Nilton Di Chiacchio

摘要

The treatment of chromoblastomycosis is still not defined, without a well-established standard treatment. It is associated with low cure and high recurrence rates, leading to long treatment. Therapy options depend on the extent of the lesions, location and patient’s comorbidities. We report an unusual case of chromoblastomycosis (Fonsecaea pedrosoi) treated exclusively with topical 5% imiquimod (5times/week for 9 months), followed by complete involution of the clinical lesions, and no recurrence after 4 years of follow-up.