This chapter examines the gendered impact of the recent genocidal war on Gaza, highlighting how these hostilities have severely hindered progress toward achieving Sustainable Development Goal 5 (SDG 5), focused on gender equality. The relentless violence, mass destruction, and killing have exacerbated existing gender inequalities and created new challenges that disproportionately affect women and girls in Gaza. By employing a qualitative research approach, this chapter draws on data from official reports, humanitarian organizations, and peer-reviewed publications to highlight the multifaceted struggles faced by women in Gaza. The war has led to a significant increase in gender-based violence, including sexual assault and discrimination, and has severely restricted access for women to essential services such as healthcare, education, and employment. The findings reveal how this unprecedented war has hindered empowerment and participation for women in society, further entrenching vulnerability and marginalization. The work underscores the critical importance of integrating gender-sensitive strategies in humanitarian interventions and post-conflict reconstruction efforts. Moreover, it advocates for international action to address these gender-specific impacts, emphasizing the need for policies and programs that support women’s rights and promote gender equality. By highlighting the severe impact of the war on the lives and livelihoods of Palestinian women, this research aims to contribute to the global discourse on gender equality in conflict zones and propose sustainable solutions to advance SDG 5 in Gaza. The call to action stresses the importance of protecting and empowering women in Gaza, recognizing their leading role in building a more equitable and resilient society.