This chapter addresses the psychosocial dimensions of end-of-life care, presenting tools and strategies that address emotional and relational needs. Grounded in the Holistic Psychosocial Care framework and guided by the Five Themes of Caring—Remember, Recognize, Respect, Reinforce, and Reminisce (5Rs)—this chapter provides a compassionate and adaptable approach to support individuals and families during life’s final transitions. Using numerous real-life cases, this chapter illustrates the complexity of navigating and supporting end-of-life. The cases and tools are organized into thematic sections, such as honoring autonomy, responding to unresponsive persons, and providing emotional and relational support. These tools are designed to align with the unique values and cultural preferences of those receiving care. This chapter aims to inspire caregivers and professionals to create person-centered, compassionate interactions.