Spiritual care is recognized as one of the four pillars of palliative care [World Health Organization (WHO definition of palliative care. https://www.who.int/news-room/fact-sheets/detail/palliative-care , 2018)] and is a vital component of the Holistic Psychosocial Model. This chapter explores the history, research, and guidelines to provide quality spiritual care along with actionable tools and real-life examples. It includes spiritual mapping, contemplative exercises, and guided visualizations designed to promote reflection and connection. Additionally, poems, prayers, and personal stories illustrate the diverse spiritual responses to mortality, encouraging care providers to approach spiritual care with humility and cultural sensitivity.