The focus on value-based care models has sparked interest among US health systems to integrate social-spatial determinants of health measures into health care. Concurrently, there has been growth in electronic health record adoption and geocoded datasets, expanding the potential for systematic approaches to incorporating these measures into care. This chapter provides a review of how US health systems are currently using social-spatial determinants of health measures in electronic health records, risk prediction, resource allocation, and reimbursement models. The chapter presents specific examples of these applications, providing a description of the measures used, data sources, and the impact of their use.