There is substantial spatial variation in healthcare access among the US Latinx population. In this chapter, we present social-spatial determinants of health framework to examine the interplay of Latinx community attributes and availability of federally qualified health centers (FQHCs). The main constructs within this framework that we operationalize are indicators of Latinx destination type (measured at the county level) and Latinx-White residential segregation (measured at the county and census tract levels). We find that FQHC supply is lower in new versus established Latinx destination counties, but there are more FQHCs in counties and tracts where Latinx segregation is higher.