This chapter examines the health impacts of historical place-based discrimination (H-PBD) on minority populations from a critical geography perspective, drawing evidence from various countries. It highlights the adverse effects of spatial segregation on health, particularly life expectancy. The article argues for comprehensive approaches addressing structural and institutional factors perpetuating health inequalities. Case studies from the cities of Philadelphia, Baltimore, and Trenton in the United States demonstrate how redlining contributed to racial and residential segregation and poverty. The article underscores the importance of recognizing intersectionality in addressing H-PBD’s role in spatial-social determinants of health.