In this chapter, we engage with how space is materialized in care relations and practices. Seeking to go beyond ideas of the “social determinants” of space, we consider space as fluid and made up in everyday practices. To do this, we work with ethnographic walking interviews generated in a participatory research project with people who use drugs and experience homelessness in London, United Kingdom. We use these data to trace how space is in the making and reflect on how place-based methods do and make space, especially for people who are without stable homes and on the move.