Geographic locations may influence social network characteristics and structures, and social networks may change one’s spatial access and mobility pattern. Such interdependence between social networks and spatial contexts is critical to consider when examining social determinants of health factors that act through them, especially in syndemics research focusing on interdependence and synergy among co-occurring diseases and social problems. In this chapter, we illustrate the dynamic process of such interdependencies and how they contribute to health inequity through differential exposure and differential vulnerability and propose a social-spatial network approach to examine health inequity in syndemics research through the lens of intersectionality.