Inland aquaculture has rapidly expanded due to the world’s need for food and aquatic resources, which poses severe environmental sustainability obstacles. Intense aquaculture practices have worsened environmental issues in land and aquatic ecosystems, notwithstanding the green, blue, and silver revolutions’ breakthroughs that increased production in various industries. Some significant issues are nutrient enrichment syndrome, groundwater and soil salinization, mangrove destruction, biodiversity loss, and aquatic pollution. Concerns regarding the long-term sustainability of the fisheries and aquaculture sectors have also been sparked by overfishing, disputes amid players over the distribution of resources and space, and international trade disputes. These problems show how urgently aquaculture has to adopt sustainable practices. This chapter examines the important causes of the existing practices’ unsustainable nature and suggests solutions. It looks at crop rotation, wastewater-fed aquaculture, integrated culture systems, and the use of probiotics and premium feed to lessen environmental impact. Other crucial elements of sustainability include socioeconomic factors, moral issues, and legal frameworks, such as transboundary ecosystem management and fishery legislation. The chapter also emphasizes the significance of the conservation of natural resources, environmental impact assessments, and ethical fishing practices. In order to attain long-term sustainability, a recommended model describes feedback loops that incorporate selective pesticide usage, better farm management techniques, and policy tools. This thorough analysis aims to offer a road map for striking a balance between ecological integrity and productivity, guaranteeing that inland aquaculture can withstand the demands of global food security.