Frailty is a major concern in gerontology and geriatrics as it may lead to disability. At the time of writing this review, 30% of the population over 65 in Europe (an in other parts of the world) are dependent on the care of other persons. It is estimated that this percentage may grow to 50% by 2050. A note of hope is that frailty (unlike aging itself) can be prevented and even reverted. Here we have reviewed two of the major lifestyle changes that are useful to treat age-associated frailty: nutrition and physical exercise. A common characteristic of both interventions is that they must be personalized. Precision interventions are now quite common in areas like oncology. A major evolution in gerontology and geriatrics should be placing more emphasis on precision, personalized interventions. Here, we have outlined general approaches to the prevention and treatment of age-associated frailty. These must be tailored to the specific needs and characteristics of each individual.