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Skin grafting cannot be used sometimes in patients with severe burns because of insufficient skin. One way of solving this problem is to use cultured epithelial autografts (CEAs): here, the cells from a small piece of epidermisEpidermis are grown in vitro into sheets that resemble conventional split-thickness skin graftsSplit-thickness skin grafts. This tissue-engineering approach was first used clinically in the early 1980s by the Green group. In 1984, they then reported that CEAs enabled the recovery of extensively burned children (O’Connor NE, Mulliken JB, Banks-Schlegel S, et al. Lancet 1:75–78, 1981; Gallico GG 3rd, O’Connor NE, Compton CC, et al. N Engl J Med 311:448–451, 1984; Gallico GG 3rd, O’Connor NE. Clin Plast Surg 12:149–157, 1985). Thereafter, the usefulness of Green-type CEAs became widely known, and CEAs are now a common treatment for extensive burn wounds (Munster AM, Weiner SH, Spence RJ. Ann Surg 211:676–679, 1990; Sood R, Balledux J, Koumanis DJ, et al. J Burn Care Res 30:576–586, 2009; Cirodde A, Leclerc T, Jault P, et al. Burns 37:964–972, 2011; Yim H, Yang HT, Cho YS, et al. Burns 37:1067–1071, 2011; Lee H. Burns 38:931–936, 2012). Another important early development in the field related to the fact that the wound bed must be prepared for successful CEA transplantation: in 1986, Cuono et al. showed that the dermal layer of allografts can be used to prepare burn wounds for CEAs (Cuono C, Langdon R, McGuire J. Lancet 1:1123–1124, 1986).

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Cultured Epithelial Autograft Transplantation on Dermal Reconstructions with Artificial Dermis

  • 章节

  • 发表日期：

    2025年

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  • Minoru Hayashi

摘要

Skin grafting cannot be used sometimes in patients with severe burns because of insufficient skin. One way of solving this problem is to use cultured epithelial autografts (CEAs): here, the cells from a small piece of epidermisEpidermis are grown in vitro into sheets that resemble conventional split-thickness skin graftsSplit-thickness skin grafts. This tissue-engineering approach was first used clinically in the early 1980s by the Green group. In 1984, they then reported that CEAs enabled the recovery of extensively burned children (O’Connor NE, Mulliken JB, Banks-Schlegel S, et al. Lancet 1:75–78, 1981; Gallico GG 3rd, O’Connor NE, Compton CC, et al. N Engl J Med 311:448–451, 1984; Gallico GG 3rd, O’Connor NE. Clin Plast Surg 12:149–157, 1985). Thereafter, the usefulness of Green-type CEAs became widely known, and CEAs are now a common treatment for extensive burn wounds (Munster AM, Weiner SH, Spence RJ. Ann Surg 211:676–679, 1990; Sood R, Balledux J, Koumanis DJ, et al. J Burn Care Res 30:576–586, 2009; Cirodde A, Leclerc T, Jault P, et al. Burns 37:964–972, 2011; Yim H, Yang HT, Cho YS, et al. Burns 37:1067–1071, 2011; Lee H. Burns 38:931–936, 2012). Another important early development in the field related to the fact that the wound bed must be prepared for successful CEA transplantation: in 1986, Cuono et al. showed that the dermal layer of allografts can be used to prepare burn wounds for CEAs (Cuono C, Langdon R, McGuire J. Lancet 1:1123–1124, 1986).