Scarring is an inevitable consequence of wound healing, and mechanical forces fundamentally influence this process at both tissue and cellular levels. This chapter mainly explores the mechanobiology of scarring in burn injuries, examining how mechanical forces regulate the transition from normal wound healing to pathological scar formation. Current understanding of mechanotransduction pathways reveals that mechanical stress significantly influences cellular behavior and tissue remodelingRemodeling through specific molecular mechanisms. In burn injuries, the importance of mechanical forces is particularly evident, as demonstrated by the high incidence of pathological scarring in areas subjected to repetitive mechanical loading during daily activities. Mechanosensitive pathways, including PIEZO1/TRPV4 channels, integrin-FAK signaling, and transcriptional regulators such as YAP/TAZ and MRTFA-SRF, form an integrated network that determines scarring outcomes. Understanding these principles has led to the development of therapeutic strategies that combine mechanical force modulation with inflammatory control. This mechanobiological perspective provides both the theoretical framework for understanding post-burn scar formation and the practical basis for therapeutic approaches in burn reconstruction, while also offering insights applicable to other forms of pathological scarring, including keloids.