The typical heart transplant (HTx) recipient often endures a poor quality of life prior to transplantation due to the sequelae of heart failure. A principal aim of transplantation is to attain an improved quality of life in addition to prolonging survival. Potential improvements in quality of life are frequently assessed when evaluating end-stage heart failure patients for transplantation. Quality-of-life can be measured both qualitatively and quantitatively. This chapter will explore aspects of quality of life in HTx, including assessing quality of life, physical well-being, functional status, employment, operating vehicles, mental health, social functioning, and reproductive health.