Cryosurgery stands as an excellent alternative to be used alone or in combination with other palliative treatment modalities. It is safe and easily performed on bedridden patients or patients constrained to a wheelchair. One session is usually sufficient. This aspect is one of the strong points in favor of cryosurgery: the reduction in the need to move the patient from one place to another for numerous sessions (as required in radiotherapy). This chapter covers the applications of cryosurgery for palliative treatment/therapy.