When cryosurgery is used for keratinocyte cancers, appropriate tumor selection and correct technique achieveing lethal tissue temperature are crucial. The Gothenburg protocols standardize cryosurgery using the open cone spray technique to ensure effective treatment. They are used for low-risk basal cell carcinoma (BCC), squamous cell carcinoma in situ (SCCis), and BCC in the periocular region, nose, and external ear. The protocols outline the cryosurgery steps and include lesion demarcation, anesthesia, curettage, the use of an open neoprene cone and fast freezing, achieving lethal temperatures visually confirmed by a 4-mm lateral spread of freeze or ‘halo.’ The endpoint is a halo thaw time of >60 seconds. Two freeze-thaw cycles are used for nodular tumors. Dermoscopic expertise is essential to make a correct clinical selection of lesions suitable for cryosurgery, and to accurately assess the tumor’s lateral demarcation before treatment.