Cryosurgery is the most commonly used single or multiple procedural individual therapy. As a field therapy, it has proven effective, but its use is much less common. The current approach when dealing with sun-damaged skin is to combine lesion therapy with field therapies. These combinations give better therapeutic results than either treatment used separately. Some common combinations are with retinoids, 5-fluorouracil, diclofenac sodium 3%, and imiquimod.