Scholarlink

There are large differences between volatile anesthetic agents and other drugs such as ketamine or Nitrous Oxide (N2O). This is where the processed Electroencephalography-Depth Of Anesthesia (pEEG-DOA) monitors start to diverge from clinical signs of anesthesia. Cortical electroencephalography (EEG) is mainly the target of γ-amino butyric acid (GABA) receptors agonists that modulate sedation and consciousness. However, ketamine and N2O, two N-methyl-D-aspartate (NMDA) receptor inhibitors induce loss of consciousness without depressing the cortical EEG. Ketamine induces loss of consciousness through a completely different mechanism of “dissociative anesthesia” other than GABA receptors. Each individual anesthetic agent, such as sevoflurane or propofol, has their own characteristic EEG “footprint” profile for calculating pEEG-DOA algorithms, that is different than other anesthetic agents: xenon, N2O, and ketamine with their unique EEG patterns than that commonly seen with other conventional general anesthetic agents.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Paradoxical Inhalational Anesthetics, Nitrous Oxide, Ketamine, and Propofol

  • 章节

  • 发表日期：

    2025年

查看全文
  • Ashraf A. Dahaba

摘要

There are large differences between volatile anesthetic agents and other drugs such as ketamine or Nitrous Oxide (N2O). This is where the processed Electroencephalography-Depth Of Anesthesia (pEEG-DOA) monitors start to diverge from clinical signs of anesthesia. Cortical electroencephalography (EEG) is mainly the target of γ-amino butyric acid (GABA) receptors agonists that modulate sedation and consciousness. However, ketamine and N2O, two N-methyl-D-aspartate (NMDA) receptor inhibitors induce loss of consciousness without depressing the cortical EEG. Ketamine induces loss of consciousness through a completely different mechanism of “dissociative anesthesia” other than GABA receptors. Each individual anesthetic agent, such as sevoflurane or propofol, has their own characteristic EEG “footprint” profile for calculating pEEG-DOA algorithms, that is different than other anesthetic agents: xenon, N2O, and ketamine with their unique EEG patterns than that commonly seen with other conventional general anesthetic agents.