This study analyses the use of game theory in designing occupational health and safety (OHS) systems, focusing on Macroergonomics and stakeholder interactions. It shows the potential of game theory to model the relationships among government, employers, and workers. This can help promote safer workplace practices and regulatory compliance. This study employs multi-party evolutionary game models to identify balanced enforcement approaches. By integrating a Macroergonomics perspective, the research prioritizes human well-being and system optimization, advocating for proactive and cooperative strategies among OHS players: workers, employers, and the government, to enhance safety outcomes and societal well-being.