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The importance of macroautophagy/autophagy across different cellular functions is demonstrated by the range of human diseases associated with autophagy dysfunction. In this chapter, you will learn about the special role of autophagy in human skeletal muscle homeostasis, delve into the spectrum of muscle diseases tied to dysfunction at various steps of the autophagy-lysosomal pathway, and understand how histopathological assessments of muscle tissues and markers of autophagosomes are used to diagnose these diseases.

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Autophagy Assessment in Diagnostic Pathology: Focus on Skeletal Myopathies

  • 章节

  • 发表日期：

    2025年

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  • Biswarathan Ramani,
  • Marta Margeta

摘要

The importance of macroautophagy/autophagy across different cellular functions is demonstrated by the range of human diseases associated with autophagy dysfunction. In this chapter, you will learn about the special role of autophagy in human skeletal muscle homeostasis, delve into the spectrum of muscle diseases tied to dysfunction at various steps of the autophagy-lysosomal pathway, and understand how histopathological assessments of muscle tissues and markers of autophagosomes are used to diagnose these diseases.