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The kidney is the organ consuming the most energy in the body, after the heart. In this chapter, we will define the metabolic needs of kidney epithelial cells to support their principal functions, such as glucose reabsorption and gluconeogenesis. The importance of sensing fluid flow (shear stress) with mechanosensors will be described, with a focus on the primary cilium. Notably, this chapter will describe the molecular machinery regulating autophagy, an important cellular process that transduces mechanical forces in biochemical responses to control the metabolism of renal cells from the proximal tubule.

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Shear Stress-Dependent Regulation of Autophagy and Metabolism in Kidney Epithelial Cells

  • 章节

  • 发表日期：

    2025年

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  • Aurore Claude-Taupin,
  • Nicolas Dupont,
  • Patrice Codogno

摘要

The kidney is the organ consuming the most energy in the body, after the heart. In this chapter, we will define the metabolic needs of kidney epithelial cells to support their principal functions, such as glucose reabsorption and gluconeogenesis. The importance of sensing fluid flow (shear stress) with mechanosensors will be described, with a focus on the primary cilium. Notably, this chapter will describe the molecular machinery regulating autophagy, an important cellular process that transduces mechanical forces in biochemical responses to control the metabolism of renal cells from the proximal tubule.