The integration of Artificial Intelligence (AI) and Extended Reality (XR) technologies is revolutionizing the supply chain industry, offering new avenues for optimizing operations and promoting sustainability. As global supply chains face increasing pressure to reduce environmental impacts, improve efficiency, and meet consumer demands for ethical practices, AI and XR emerge as transformative tools that can drive substantial improvements. AI enables predictive analytics, real-time decision-making, and automation, while XR technologies, including virtual reality (VR) and augmented reality (AR), enhance collaboration, training, and logistics management. Together, these technologies are helping businesses reduce waste, optimize resource allocation, and streamline production processes, ultimately contributing to more sustainable practices. This chapter explores the role of AI and XR in transforming supply chain management, highlighting their potential to enhance transparency, improve energy efficiency, and promote circular economy models. Through case studies and examples, the chapter demonstrates how these technologies are not only enhancing operational efficiency but also fostering a more sustainable and resilient supply chain for the future.