This chapter explores the complex interplay between digital addiction, depression, and suicide, emphasizing their significant impact on mental health. It examines connections between excessive digital technology use and psychological disorders such as depression and suicidal ideation, while addressing the risk and protective factors that influence these outcomes. The role of digital environments is critically analyzed, revealing their potential to both exacerbate and mitigate mental health challenges. Key mechanisms—such as social comparison, exposure to harmful content, and cyberbullying—intensify feelings of loneliness, inadequacy, and hopelessness. The chapter highlights the bidirectional relationship between digital addiction and mental health issues, where psychological vulnerabilities drive excessive screen time, perpetuating a cycle of negative outcomes. Neurobiological insights reveal how compulsive digital behaviors disrupt brain reward systems, impair emotional regulation, and weaken cognitive functioning. To address these challenges, the chapter advocates for preventive measures and interventions, including digital literacy programs, screen time management, and cognitive-behavioral therapy (CBT). It underscores the importance of fostering resilience, promoting balanced technology use, and implementing multidisciplinary approaches to mitigate the adverse effects of digital addiction on mental health.