Based on the underpinning and rectification project of a frame structure building with pile foundations, this paper studied the jacking technology of underpinning pile reinforcement and analyzed the issue of structural tilt distortion caused by the differential settlement. The reasons of differential settlement, such as climate, collapsibility, under-consolidation of soil, and other factors, were thoroughly examined, and appropriate reinforcement strategies were suggested. The project employed micro-piles for settlement relief and underpinning, performed rectification construction using underpinning piles, and used jacking technology to lower or locally jack the building in order to rectify the tilt. The PLC synchronous jacking control platform was used to precisely regulate the jack’s lifting capacity and guaranteed the structure’s safety during the jacking process. To improve the structural stability, grout wass used to fill the space beneath the foundation after jacking. The project had a good economic and social value, saving construction time and costs, and successfully meeting its objectives. In addition, this paper offered some recommendations that serve as a guide for the correlated projects, including pre-load inspection before jacking, consideration of stress concentration throughout the jacking operation, and construction quality of important connections.