This chapter analyses the environmental, social, and ethical challenges associated with the farming of key aquaculture species: tiger prawns, king prawns, Atlantic salmon, and tilapia. These species dominate global aquaculture, providing a crucial source of protein and economic livelihoods but also contributing to significant environmental degradation and social injustices. The chapter outlines the environmental impacts of aquaculture, including water pollution, habitat destruction, and the overuse of antibiotics, which exacerbate biodiversity loss and contribute to the emergence of antibiotic-resistant pathogens. Social issues such as labour exploitation, including instances of human trafficking and unsafe working conditions, are examined in the context of prawn and fish farming industries in regions such as Southeast Asia, South America, and Africa. The ethical implications of farming sentient creatures in intensive, high-density systems are also explored, with attention to welfare concerns and inadequate regulatory frameworks. The chapter concludes by highlighting the need for sustainable aquaculture practices and innovative alternatives to balance global food security, economic benefits, and ecological resilience.