This chapter provides an overview of how to effectively assess the impact of digital health solutions on core objectives of high-performing health systems at the patient, provider, and system levels. Key measures of impact on patient outcomes and experience, provider experience, system efficiency, and equity related to digitally enabled models of care are outlined to help evaluators understand how impact can be measured. To effectively capture this impact, this chapter outlines how commonly used evaluation approaches can be adapted to adequately capture digitally enabled services and highlights the importance of adopting developmental and design thinking to evaluate these types of interventions. The chapter finishes with some guidance on choosing among the different approaches when considering capturing the impact on the quintuple aim.