The article is devoted to the study of innovative technologies and their impact on the organizational and economic mechanism of sustainable development of tourism in Uzbekistan. It considers key innovation trends, such as digitalization, the use of artificial intelligence and eco-innovation, and their role in improving economic efficiency and sustainability of the industry. Examples of successful international experience are analyzed, as well as measures of state support for innovation processes implemented in Uzbekistan. Particular attention is paid to public–private partnership programs and support for start-ups in tourism. In conclusion, recommendations for further improvement of innovation mechanisms for the development of sustainable tourism in the country are offered.