The objective of regenerative medicine is to reverse the ageing process of the body by utilising its inherent capacity for healing by repairing, restoring, and regenerating tissues and organs that have been harmed by an injury, congenital flaw, or disease. Using nanotechnology to deliver precise medications to predetermined areas and targets has several advantages in the treatment of chronic human diseases. Numerous sorts of structures have been researched and used to treat chronic disorders, and nanotechnology is showing considerable therapeutic promise. The creation of biomimetic materials for cell integration as well as innovative medication delivery and targeted systems that can lower drug-related, long-term adverse effects have all been made possible by technological advancements. Tissue regeneration is made accessible by the inclusion of cells in biomimetic materials made using nanotechnology. In the field of medicine, lipid-based nanoparticles have emerged as effective delivery systems for many kinds of therapeutic pharmaceuticals. The goal is to highlight the findings of recent research using nanotechnologies to treat tissue regeneration in chronic disorders. The use of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate well, leading to successful tissue regeneration, is also discussed here along with the significance of biomaterials in tissue engineering.