Biodegradation Behavior of Magnesium-Based Biomaterials Using Surface Modification Techniques for Orthopedic Implants: A Review
摘要
Magnesium (Mg)Magnesium (Mg) based biomaterials have emerged significantly to improve the biodegradationBiodegradation and biocompatibility for orthopedic implants. The major limitation of Mg-based implants is their rapid biodegradation, evolution of hydrogen gas and loss of mechanical integrity before bone tissue recovery in the physiological environment. Ion Implantation, Plasma Spraying, Laser Surface Modification, Plasma Electrolytic Oxidation (PEO) andPlasma electrolytic oxidation (PEO) Surface CoatingCoating techniques are reviewed for improving the mechanical, biodegradation, bioactivity and biocompatibility behavior of Mg based materials. Biodegradable Poly (lactic acid) (PLA)Poly lactic acid (PLA), its copolymers with polycaprolactone (PCL), glycolic acid (PLGA), and polyhydroxy butyrate (PHB) are also suitable for improving the biodegradationBiodegradation and biocompatibility of the implant but limited due to their poor adhesion with the Mg substrate. Surface modification followed by polymer coating/hybrid coating on Mg-based implants is explored and mechanical, biodegradation and biocompatibility behavior in physiological environment is reviewed and discussed.