In this digital age, the prevalence of telework has increased notably, catalysed by the COVID-19 pandemic. Since 2019, the share of employees working from home nearly doubled. This brought a long considerable changes in the day-to-day work situation of many employees. Using data from the European Working Conditions Survey (EWCS) for 2015 and 2021 covering the EU27, this chapter examines how different telework modalities—no, occasional, or full-time telework—are associated with a range of psychosocial risks, namely work intensity, work-life interference, low social support, and low job control. Furthermore, this chapter maps these associations with gender, age and education level. The main psychosocial risks are examined via in-depth analyses to identify groups of employees considered at-risk for experiencing high levels of psychosocial risks depending on the telework modality. These findings contribute to ensuring good working conditions for employees in different telework modalities.