Cognitive-behavioral approach psychological intervention programs for informal caregivers of Alzheimer’s patients have so far been the most used due to the effectiveness of their results. The objective of this study is the implementation of the PIRCA program (Resilience Intervention Program for Informal Caregivers of Alzheimer’s patients) to observe the changes presented in the subjects after participating in the program. Ten informal caregivers participated, who were unpaid, untrained, and lived with the patient. A comparative descriptive cross-sectional experimental study was designed, pretest/posttest type. The results indicated that the scores of the variables with the highest variability were depression state, euthymic state, overload, and coping strategies such as seeking social support and religion. It is concluded that intervening resilience responds to a basic need of caregivers as it is present in the caregiver’s personality characteristics.