Generational trauma, influenced by collective histories of discrimination and violence, has profound psychological, social, and biological effects. Trauma transmission occurs through various mechanisms, including intergenerational and transgenerational pathways, affecting not only those directly exposed but also future generations. This process can lead to mental and physical health disparities, particularly within marginalized communities. Understanding trauma’s transmission is vital for developing culturally informed, trauma-sensitive care. This chapter discusses types of generational trauma, including historical and cumulative, and explores the biopsychosocial model for assessing trauma’s impact, highlighting the importance of epigenetics and sociocultural factors in shaping health outcomes.