It is widely acknowledged that inflammatory bowel disease can seriously affect all aspects of daily life. Furthermore, many patients report that stress exacerbates their symptoms (Robertson et al., Gut 30:623–626, 1987; Luber et al., JGH Open 6:76–84, 2022) and this is supported by clinical studies which indicate that chronic stress and life events can cause relapse in patients with IBD (Mawdaley and Rampton, Gut 54:1481–1491, 2005). Therefore, better management of stress has potentially crucial implications for patients and healthcare professionals. It can improve resilience and develop more adaptive coping mechanisms. However when this is not achieved, psychological distress in the form of depression, anxiety, and post-traumatic stress disorder can take over which in a vicious cycle impairs further the ability to handle stress. This chapter will look at the various stress factors which are unique to IBD and how the IBD nurse can psychologically support the patient in daily practice, and in turn look at how the nurse can be supported in order to support the patient.