Inflammatory bowel disease (IBD) is an unpredictable, complex, and chronic condition with symptoms that are unpleasant, embarrassing, and painful. The global incidence is rising though the majority of patients will remain capable of leading a reasonably normal life (Haynes, Introduction, in: Haynes et al., eds., Compliance in health care, Johns Hopkins University Press, Baltimore, 1979, pp. 1–7). Individuals with IBD will often require intensive on-going input from health professionals. The chronic nature and increasing incidence of IBD demand healthcare innovations to guarantee future high-quality care. This chapter considers specific considerations for nurses and other healthcare professionals managing adherence in IBD to improve the quality of care. Understanding the patient perspective and being willing to listen to them might be the keys to change.