With a growing number of effective treatment options for patients with inflammatory bowel disease (IBD), it is more important than ever for providers to understand the risks associated with different medication classes. Patients identify their care team as the most reliable source of information about treatment, so we need to be prepared to answer questions and address concerns. Overall, the treatments available for IBD are very safe, but there are some important possible side effects that patients should be aware of before starting on therapy. In addition to knowing the data, the care team must be able to communicate this information to patients to ensure that an informed shared medical decision can be made together.