This chapter examines generic health status measures used in healthcare such as the SF-36 and its derivative SF-12, EQ-5D, and the howRu measure. Health status measures are used to assess patient-centred outcomes, treatment effectiveness, and quality of life. SF-36 and SF-12 are widely used in clinical research, while EQ-5D supports economic appraisals through quality-adjusted life years (QALYs). The newer howRu measure focuses on brevity and simplicity for routine clinical use. The chapter includes comparative studies showing how different measures show varying effect sizes, impacting clinical and economic decisions. It highlights differences between the Oxford Hip and Knee scores and EQ-5D scores in assessing joint replacement outcomes. The chapter also discusses recall periods, readability, and scoring systems, emphasizing practical considerations in choosing appropriate tools. By optimizing health status measurement, healthcare providers can better monitor individual and population health, evaluate interventions, and enhance patient care through timely, actionable feedback.