Traumatic brain injury (TBI) affects individuals of all genders, but women may experience TBI differently from men, in terms of both physiological responses and long-term outcomes. This chapter, therefore, will place a spotlight on TBI in women, a historically under-researched and under-recognized area. It is important to center the discussion in the broader context of TBI and so the chapter will begin with a brief introduction to the basics of TBI, including defining clinical characteristics and pathophysiology, prevalence and incidence rates, mortality and morbidity, and demographic-related risk factors. This general discussion will give way to the unique factors that play a role in the risk of TBI for women, and how these factors may influence differences in symptom presentation, recovery trajectories, and long-term outcomes post-injury. We will address special populations and settings where head injuries commonly occur but are particularly understudied among women including sports-related concussion, military service, and intimate partner violence. Finally, we will detail clinical and research takeaways. By understanding these nuanced gender differences, healthcare providers can better address the unique needs of women who have sustained a TBI and improve their overall quality of care and life.