This chapter empirically explores the relationship between demographic and economic characteristics of individuals and the proportion of Colorado’s electorate voting to legalize psychedelic drugs in Colorado in 2022. Proposition 122, introduced with the ballot, offered voters the option to support or reject the legal use of psychedelics. Utilizing county-level data on political party registrations, education, gender, median age, median income, and controls for if a county is urban, we find evidence that there is a positive, statistically significant relationship between the share of Democratic registered voters and the proportion of voters approving Proportion 122. This chapter serves as an application of the Median Voter Theorem in evaluating how characteristics of Colorado voters impact the legalization of psychedelic drugs.