Of all the cranial nerves, the abducens nerve has the longest course within the skull. The abducens nucleus is in the caudal pons right in front of the fourth ventricle. Its fibers run horizontally through the brainstem and then exit the brainstem and then make a sharp turn to travel superiorly between the pons and the clivus, deep to the dura mater, in Dorello’s canal. They then enter the cavernous sinus, travel through the superior orbital fissure, and reach the lateral rectus muscle. There are numerous locations where CN VI can be lesioned.