This work succinctly expresses a prolonged reflection on the topic of the role of the Humanities in 21st century medicine. My thinking process has been complex, disturbing and sometimes desolate. Perhaps it is the first time in the history of humanity that the future appears unfathomable and totally unpredictable. This reality includes not only limitless scientific and technological aspects but also an anthropological conception of human beings. By the end of this century they will be so different that perhaps they will no longer recognize themselves as such. These ‘posthumans’ or ‘transhumans’ are so unimaginable to us that we will not dare to value their thoughts, decisions and actions. This is, as I have said, a disturbing subject that will change the conception of person, identity, culture and society forever. So this reflection turns out to be, a limited way of groping that future.