Climate change represents a profound and escalating threat to global public health, undermining decades of progress over the past 50 years and exacerbating vulnerabilities worldwide. Its impacts span direct health effects, such as those from extreme heat and weather events, to indirect challenges, including ecosystem disruptions, food insecurity, and socio-economic crises like displacement, poverty, and conflict. The disproportionate burden on marginalized populations, particularly in low-income regions, underscores the urgent need for equitable and inclusive strategies. However, existing research on the health implications of climate change is often siloed, limiting the integration of insights and hindering the identification of critical gaps. Compounding this challenge is the rapid proliferation of literature, which outpaces traditional evidence review methods. Recent extreme weather events—record-breaking heatwaves, catastrophic floods, widespread wildfires, and prolonged droughts—have further highlighted the interconnectedness of environmental, animal, and human health. To confront these complex, multi-dimensional issues effectively, interdisciplinary frameworks such as One Health and Ecohealth offer promising pathways for collaborative action. This paper explores the intersections of climate change and health, advocating for the application of these integrative approaches to foster timely, comprehensive, and actionable public health responses.