The processing of palm fruit into crude oil results in the production of various residues, of which liquid effluents are the most significant, with 0.5–0.8 m3 of effluents produced per ton of processed seed bunches. The systems put in place to treat this waste have revealed some shortcomings and still entail several environmental risks. To remedy this situation, an alternative is being considered: anaerobic digestion, which is recognized as a sustainable process. In addition to treating palm oil mill effluent, this technology offers the prospect of making this activity profitable through the production of energy (gas, heat, electricity). However, given the high acidity (pH = 4.74), load (COD = 60,716 mg O2/ L) and VFA content (VFA = 5000.33 mg/L) of palm oil mill effluent, it will be important to monitor these parameters during digester tests to reduce the risk of acidosis, a limiting factor in methane production. BMP tests carried out over 29 days at a constant temperature of 37°C, using sludge from a stationary digester as inoculum, revealed a methane yield of 170.26 Nml CH4/g VS. This shows that palm oil mill effluent is an excellent source of renewable energy. To stabilize the reaction medium and achieve these yields on a larger scale, we need to find more suitable and optimal parameters.