Mango (Mangifera indica) cultivation is a cornerstone of tropical agriculture, offering economic and nutritional benefits worldwide. However, the increasing frequency and intensity of diseases driven by climate change threaten its production. Advances in technology, from drone-based imaging to artificial intelligence (AI), have provided novel solutions for monitoring and managing these challenges. This chapter explores the latest innovations, including remote sensing, Internet of Things (IoT) devices, metagenomics, and robotics, and their role in enhancing resilience against climate-induced disease dynamics. These technologies offer scalable, sustainable strategies for disease management, bridging gaps between traditional practices and modern solutions.