Road vehicles are the main cause of the transportation sector's greenhouse gas emissions. However, there are a few studies that provide empirical evidence for assessing the potential of changing the transportation system to reduce the level of greenhouse gas emissions. In this context, the analysis of the amount of carbon emissions from different transportation systems, including rail, road (highway), marine and air (civil) transport, under different policies and measures has been widely documented and done in recent years. Through this paper, I set out to see how close the connection is between fuel consumption and the amount of CO2 emissions, in hybrid vehicles, on the one hand, and on the other hand, how other parameters such as: engine power, engine speed, and total engine capacity influence the amount of CO2 emissions, using multiple regression. The results showed that there is a direct and strong link between fuel consumption and the amount of CO2 emissions, given that the value of the correlation coefficient tends to 1 (0.9752). The simple linear regression equation shows that CO2 emissions increase on average by approximately 13.01 g/km if fuel consumption increases by 1 l/100 km. The value of R2 shows that 95.1% of the variation in the amount of CO2 emissions is explained by the variation in fuel consumption. The difference up to 100% is explained by the dependent variables: engine power, engine speed, total engine capacity, and other parameters which were not considered.